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VERSION:2.0
PRODID:-//University of Liverpool Computer Science Seminar System//v2//EN
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DTSTAMP:20260922T121734Z
UID:Seminar-MIF-1438@lxserverM.csc.liv.ac.uk
ORGANIZER:CN=Othon Michail:MAILTO:Othon.Michail@liverpool.ac.uk
DTSTART:20240930T140000
DTEND:20240930T150000
SUMMARY:MIF Series
DESCRIPTION:Erica L. Flapan: A tile model of entangled proteins\n\n It has been established that knots, slipknots, and other complex topologies exist in cellular proteins and have been conserved throughout evolution. Yet the global topology of a chain only provides a limited view of its topological entanglement. Even if the chain is unknotted, there can be tangling of sites which may be distant on the amino acid sequence but are twisted together and held in place by molecular forces. We model this type of entanglement by starting with a collection of 1-string and 2- string tiles that are based on local entanglements that have been observed in protein chains. We then combine our tiles according to a well defined set of operations. Using the algebra of tiles and operations we symbolically represent all entanglements that can be built up in this way, and determine which knot types can occur.\n\nhttps://www.csc.liv.ac.uk/research/seminars/abstract.php?id=1438
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