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PRODID:-//University of Liverpool Computer Science Seminar System//v2//EN
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DTSTAMP:20260922T101441Z
UID:Seminar-MIF-1404@lxserverM.csc.liv.ac.uk
ORGANIZER:CN=Othon Michail:MAILTO:Othon.Michail@liverpool.ac.uk
DTSTART:20230224T140000
DTEND:20230224T150000
SUMMARY:MIF Series
DESCRIPTION:Luigi Vitagliano: The fine structure of proteins: detection, characterization and implications. Part 1.\n\nProteins combine an extraordinary structural complexity with fine structural regulations that operates in response to environmental stimuli. Indeed, fundamental protein activities often rely on extremely subtle structural features that are frequently dictated by physical forces of limited strengths. Therefore, the elucidation of the basis of protein functionalities frequently requires accurate determinations of their intricate structures. Exploiting the impressive amount of data reported in structural databases (PDB and CSD), we have highlighted the interplay occurring between the geometry of the peptide bond, expressed in terms bond lengths, valence bond and plane distortions, and the local conformation of the polypeptide chains. The elucidation of this correlation has interesting implications (a) for protein structure validation and quality assessment, (b) for the definition of the structural bases of amino-acid conformational preferences, (c) for the identification of secondary forces impacting protein structures, and for the evaluation of force fields commonly used in molecular modelling and dynamics.\n\nhttps://www.csc.liv.ac.uk/research/seminars/abstract.php?id=1404
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